GC (Vitamin D Binding Protein) rs2282679

Gene function:
The GC gene (Group-specific Component) encodes the vitamin D binding protein (VDBP), which transports and distributes vitamin D throughout the body. Individuals who are homozygous or heterozygous have lower circulating 25-hydroxy vitamin D3 than subjects with normal genotypes. These individuals are more prone to deficiency and may require higher dietary intake to maintain optimal levels.

Effect of the SNP:
Both +/+ and +/- genotypes are associated with lower circulating vitamin D levels.

Specialized nutritional support*:
Vitamin D3

The multivitamin is optional foundational support

BCMO1 (ß-Carotene 15,15’-monooxygenase 1) R267S

Gene function:
BCMO1 encodes an enzyme in the small intestinal mucosa that catalyzes a critical step in the conversion of beta-carotene to vitamin A. Vitamin A is essential for immune function, vision, growth, reproductive function and cellular health.*

Effect of the SNP:
The R267S and A379V polymorphisms reduce the activity of the BCMO1 enzyme, which converts dietary beta-carotene to active vitamin A. Human studies have associated these SNPs with lower circulating vitamin A levels, with and without beta-carotene supplementation. Female volunteers with 379V exhibited a 32% reduction in the ability to generate vitamin A from dietary beta-carotene. Subjects who were hetero- or homozygous for both R267S and A379V had a 69% reduction in conversion efficiency.

Specialized nutritional support*:
Preformed vitamin A (retinol)

The multivitamin is optional foundational support

BCMO1 (ß-Carotene 15,15’-monooxygenase 1) A379V

Gene function:
BCMO1 encodes an enzyme in the small intestinal mucosa that catalyzes a critical step in the conversion of beta-carotene to vitamin A. Vitamin A is essential for immune function, vision, growth, reproductive function and cellular health.*

Effect of the SNP:
The R267S and A379V polymorphisms reduce the activity of the BCMO1 enzyme, which converts dietary beta-carotene to active vitamin A. Human studies have associated these SNPs with lower circulating vitamin A levels, with and without beta-carotene supplementation. Female volunteers with 379V exhibited a 32% reduction in the ability to generate vitamin A from dietary beta-carotene. Subjects who were hetero- or homozygous for both R267S and A379V had a 69% reduction in conversion efficiency.

Specialized nutritional support*:
Preformed vitamin A (retinol)

The multivitamin is optional foundational support

SLC30A8 rs11558471

Gene function:
ZnT8 is a zinc transporter encoded by the SLC30A8 gene. It is responsible for maintaining zinc homeostasis in certain tissues such as the pancreas, where zinc is needed to maintain the stability and proper secretion insulin.

Effect of the SNP:
The A allele may affect zinc requirements

Specialized nutritional support*:
Zinc

SLC23A1 rs33972313

Gene function:
SLC23A1 a membrane transporter that enables vitamin C to cross cell membranes. It plays an important role in vitamin C absorption.

Effect of the SNP:
The A allele is associated with lower circulating vitamin C levels

Specialized nutritional support*:
Ascorbic acid or buffered ascorbic acid

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Sample Report

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