GPx1P1 Pro198Leu

Gene function:
Glutathione peroxidase P1 (GPx1P1) is one of the most important antioxidant enzymes in the body. It detoxifies hydrogen peroxide, a reactive oxygen species, by converting it to water.

Effect of the SNP:
This SNP is associated with reduced enzyme activity.

Specialized nutritional support*:
GPx1P1 requires selenium as a cofactor and glutathione as an electron donor. N-acetyl-l-cysteine (NAC) and alpha lipoic acid support endogenous glutathione biosynthesis. Vitamin C assists in the removal of ROS, including hydrogen peroxide, and the regeneration of reduced glutathione. Cruciferous vegetables, sulforaphane, diindolylmethane (DIM) and alpha lipoic acid support expression of glutathione cysteine ligase, which catalyzes a crucial in glutathione biosynthesis.

GSTP1 (Glutathione Sulfotranferase Pi 1) I105V

Gene function:
Glutathione S-transferase P1 (GSTP1) is a phase II detoxification enzyme. It attaches glutathione to many types of toxins, reducing their activity and facilitating their elimination.

Effect of the SNP:
This SNP is associated with reduced enzyme activity.

Specialized nutritional support*:
Glutathione participates directly in the conjugation reactions mediated by GSTP1. N-acetyl-l-cysteine and alpha lipoic acid support endogenous production of glutathione. Cruciferous vegetables support GST expression in a variety of tissues, and evidence suggests that women with this SNP should increase intake of these foods to maintain breast health. Bioactives and metabolites from broccoli, such as sulforaphane and diindolylmethane (DIM), promote both GST expression and glutathione biosynthesis.

SOD2 (Manganese Superoxide Dismutase 2) VAL16ALA

Gene function:
The SOD2 gene encodes manganese superoxide dismutase, the primary antioxidant enzyme in the mitochondria. It neutralizes reactive oxygen species (ROS) known as superoxide anions, forming hydrogen peroxide, which is a weaker form of ROS.

Effect of the SNP:
This SNP creates an imbalance in the intracellular levels of SOD2. This affects antioxidant defenses against superoxide anions and possibly hydrogen peroxide.

Specialized nutritional support*:
Astaxanthin, a carotenoid antioxidant, moderates both superoxide and hydrogen peroxide in the mitochondria and in the cytosol. Astaxanthin also supports healthy levels of SOD2. Vitamin C helps to protect the interior (matrix) of the mitochondria from superoxide and hydrogen peroxide. Sulforaphane, diindolylmethane (DIM) and alpha lipoic acid support antioxidant gene expression.

CYP1A2 rs762551 (CYP1A2*1F)

Gene function:
CYP1A2 (cytochrome P450 1A2) is a phase I detoxification enzyme that metabolizes caffeine and certain toxins.

Effect of the SNP:
The C allele reduces enzyme function, resulting in slow metabolism of caffeine. This SNP also affects the metabolism of certain toxins.

Specialized nutritional support*:
Limit caffeine intake. If necessary, consider energy-promoting adaptogenic herbs, such as those in Energy Xtra.*

NQO1 rs1800566 (C609T; Pro187Ser)

Gene function:
NQO1 is an enzyme that helps to protect cells from oxidative stress, in part by keeping various endogenous antioxidants in their active forms. NQO1 also participates in the metabolism of certain toxins.

Effect of the SNP:
The T allele is associated with reduced enzyme activity.

Specialized nutritional support*:
Nrf2 Detox provides sulforaphane and other compounds that support detoxification by supporting the Nrf2 pathway, which regulates NQO1 expression.*

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Sample Report

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