GPx1P1 Pro198Leu

Gene function:
Glutathione peroxidase P1 (GPx1P1) is one of the most important antioxidant enzymes in the body. It detoxifies hydrogen peroxide, a reactive oxygen species, by converting it to water.

Effect of the SNP:
This SNP is associated with reduced enzyme activity.

Specialized nutritional support*:
GPx1P1 requires selenium as a cofactor and glutathione as an electron donor. N-acetyl-l-cysteine (NAC) and alpha lipoic acid support endogenous glutathione biosynthesis. Vitamin C assists in the removal of ROS, including hydrogen peroxide, and the regeneration of reduced glutathione. Cruciferous vegetables, sulforaphane, diindolylmethane (DIM) and alpha lipoic acid support expression of glutathione cysteine ligase, which catalyzes a crucial in glutathione biosynthesis.

GSTP1 (Glutathione Sulfotranferase Pi 1) I105V

Gene function:
Glutathione S-transferase P1 (GSTP1) is a phase II detoxification enzyme. It attaches glutathione to many types of toxins, reducing their activity and facilitating their elimination.

Effect of the SNP:
This SNP is associated with reduced enzyme activity.

Specialized nutritional support*:
Glutathione participates directly in the conjugation reactions mediated by GSTP1. N-acetyl-l-cysteine and alpha lipoic acid support endogenous production of glutathione. Cruciferous vegetables support GST expression in a variety of tissues, and evidence suggests that women with this SNP should increase intake of these foods to maintain breast health. Bioactives and metabolites from broccoli, such as sulforaphane and diindolylmethane (DIM), promote both GST expression and glutathione biosynthesis.

SOD2 (Manganese Superoxide Dismutase 2) VAL16ALA

Gene function:
The SOD2 gene encodes manganese superoxide dismutase, the primary antioxidant enzyme in the mitochondria. It neutralizes reactive oxygen species (ROS) known as superoxide anions, forming hydrogen peroxide, which is a weaker form of ROS.

Effect of the SNP:
This SNP creates an imbalance in the intracellular levels of SOD2. This affects antioxidant defenses against superoxide anions and possibly hydrogen peroxide.

Specialized nutritional support*:
Astaxanthin, a carotenoid antioxidant, moderates both superoxide and hydrogen peroxide in the mitochondria and in the cytosol. Astaxanthin also supports healthy levels of SOD2. Vitamin C helps to protect the interior (matrix) of the mitochondria from superoxide and hydrogen peroxide. Sulforaphane, diindolylmethane (DIM) and alpha lipoic acid support antioxidant gene expression.

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Sample Report

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